Verfasst: 17 Dez 2010 11:50
Texte habe ich aus dieser Seite entnommen: http://www.ivfauthority.com/search/labe ... %20therapy (von Dr. G. Sher)
More About Immunologic Implantation Dysfunction (IID)
Alloimmunity (where a reaction occurs against antigens derived from another member of the same species) is believed to be a relatively common immunologic cause of recurrent pregnancy loss.
A pregnancy must be recognized by the mother’s body as a foreign object to trigger the appropriate immunologic mechanisms which allow the embryo to implant and grow. Sometimes when a male partner transmits (via his sperm contribution to the embryo) certain genes that are too similar to the mother’s genetic make-up, the immune system rejects the embryo. Such rejection usually takes the form of an early miscarriage but sometimes (rarely) the rejection can be so abrupt as to completely prevent recognition of a pregnancy. In such cases, the couple might present with “unexplained infertility” or “unexplained IVF failure.”
Alloimmune implantation dysfunction is a common immunologic cause of recurrent pregnancy loss .Testing for alloimmune similarities is thus a very important part of the evaluation of non-chromosomal recurrent pregnancy loss. It requires comparing the mothers and father’s HLA and DQ alpha status (see below). When the sperm provider and the embryo recipient share several HLA antigens (e.g HLA, B, C, DR, DQ or DP), implantation failure can occur, manifesting as RPL or even as sometimes as unexplained IVF failure.
Autoimmunity refers to an immunologic reaction produced by the individual to his/her body’s own cellular components. The most common antibodies that form in such situations are: a) Anti-phospholipid antibodies (APA) b) Antithyroid antibodies (ATA) c) Antiovarian antibodies. But, it is only when specialized immune cells in the uterine lining known as Natural Killer Cells, become activated (NKa) and start to release “toxins” that attack the root system of the embryo, that implantation potential is jeopardized. Diagnosis of such NK cell activation (Nka) requires highly specialized blood and/or endometrial tests that can only be performed in a handful of reproductive immunology laboratories in the United States. Since Autoimmune Implantation Dysfunction is often genetically transmitted, it is not surprising that it is more likely to exist in women who have a family (or personal) history of primary autoimmune diseases such as Lupus Erythematosus (LE), Scleroderma, clinical or subclinical hypothyroidism, Rheumatoid Arthritis, etc. Reactionary (secondary) autoimmunity can occur in conjunction with any medical condition associated with widespread tissue damage. One such gynecologic condition is endometriosis. Autoimmune implantationdysfunction is usually lethal to the implanting embryo. This is because it destroys the embryo’s root system from the get-go. Accordingly, it most commonly presents as “unexplained infertility” or “unexplained (often repeated) IVF failure” rather than as a miscarriage. Autoimmune Implantation dysfunction is readily amenable to reversal through timely, appropriately administered, selective immunotherapy (see below).
Du kannst auf der Seite die Therapien nachlesen weiter unten. und dann noch diese Seite: http://www.ivfauthority.com/search/labe ... er%20cells (dort musst du zum 2. Artikel runterscrollen) dort geht es um das DQa, was Anfi erwähnte und auch um IVIG und IL.
Alles Gute, Richy
More About Immunologic Implantation Dysfunction (IID)
Alloimmunity (where a reaction occurs against antigens derived from another member of the same species) is believed to be a relatively common immunologic cause of recurrent pregnancy loss.
A pregnancy must be recognized by the mother’s body as a foreign object to trigger the appropriate immunologic mechanisms which allow the embryo to implant and grow. Sometimes when a male partner transmits (via his sperm contribution to the embryo) certain genes that are too similar to the mother’s genetic make-up, the immune system rejects the embryo. Such rejection usually takes the form of an early miscarriage but sometimes (rarely) the rejection can be so abrupt as to completely prevent recognition of a pregnancy. In such cases, the couple might present with “unexplained infertility” or “unexplained IVF failure.”
Alloimmune implantation dysfunction is a common immunologic cause of recurrent pregnancy loss .Testing for alloimmune similarities is thus a very important part of the evaluation of non-chromosomal recurrent pregnancy loss. It requires comparing the mothers and father’s HLA and DQ alpha status (see below). When the sperm provider and the embryo recipient share several HLA antigens (e.g HLA, B, C, DR, DQ or DP), implantation failure can occur, manifesting as RPL or even as sometimes as unexplained IVF failure.
Autoimmunity refers to an immunologic reaction produced by the individual to his/her body’s own cellular components. The most common antibodies that form in such situations are: a) Anti-phospholipid antibodies (APA) b) Antithyroid antibodies (ATA) c) Antiovarian antibodies. But, it is only when specialized immune cells in the uterine lining known as Natural Killer Cells, become activated (NKa) and start to release “toxins” that attack the root system of the embryo, that implantation potential is jeopardized. Diagnosis of such NK cell activation (Nka) requires highly specialized blood and/or endometrial tests that can only be performed in a handful of reproductive immunology laboratories in the United States. Since Autoimmune Implantation Dysfunction is often genetically transmitted, it is not surprising that it is more likely to exist in women who have a family (or personal) history of primary autoimmune diseases such as Lupus Erythematosus (LE), Scleroderma, clinical or subclinical hypothyroidism, Rheumatoid Arthritis, etc. Reactionary (secondary) autoimmunity can occur in conjunction with any medical condition associated with widespread tissue damage. One such gynecologic condition is endometriosis. Autoimmune implantationdysfunction is usually lethal to the implanting embryo. This is because it destroys the embryo’s root system from the get-go. Accordingly, it most commonly presents as “unexplained infertility” or “unexplained (often repeated) IVF failure” rather than as a miscarriage. Autoimmune Implantation dysfunction is readily amenable to reversal through timely, appropriately administered, selective immunotherapy (see below).
Du kannst auf der Seite die Therapien nachlesen weiter unten. und dann noch diese Seite: http://www.ivfauthority.com/search/labe ... er%20cells (dort musst du zum 2. Artikel runterscrollen) dort geht es um das DQa, was Anfi erwähnte und auch um IVIG und IL.
Alles Gute, Richy
werde aber am WE alles ganz in Ruhe durchlesen. Muss auch in meinen Unterlagen schauen, ob HLA C und DqA getestet wurden, ich habe mir nur die Übereinstimmungen gemerkt. Also evtl. doch keine Immunisierung? Werde mich belesen. Nochmals großes Dankeschön, ihr seid echt wahnsinnsklasse!!!!! 
ich drücke dir alle daumen das alles gut geht! wenn du mich fragst, kannst du die granos auch weglassen... wenn RF das schon sagt dann brauchst du es auch nicht... denke du bist mit den Prednisilon und IVIGs gut versorgt! wann du ASS und Heparin nimmst ist zeitlich egal.
- na da ist alles entschuldigt 
würd ich mal sagen - und der HCG ist super für ES+12 - ich hatte 73 und dann 3 Tage später 290
.... Und es ist absolut ungerecht .... Aber ihr habt die Option der EZS und wie du schreibst, müssen es dieses Mal ja wieder gute EZ sein.